Glacios 2 Cryo‑TEM

Capabilities

• 200 kV cryogenic transmission electron microscope optimized for high-resolution imaging of biological macromolecules.
• High throughput cryo‑TEM image acquisition: fringe‑free imaging (FFI).
• Automated cryo‑EM software maximizes ease of use and efficiency: EPU and Leginon.
• Cryo‑EM sample screening and workflow connectivity.
• Cryo‑ET and MicroED.

Applications

• Determining 3D atomic structures of proteins, complexes, and assemblies (100 kDa – megadalton scale); membrane proteins in nanodiscs or detergents; and for structure‑based drug discovery.
• Cryo‑electron tomography for cells or tissues in near‑native state when combined with cryo‑FIB.
• Fringe‑free imaging enables fast cryo‑grids screening.
• Supports pharma pipelines for rational drug design.
• MicroED enables structure determination for small crystal of protein.

Access & Training

• Available to FSU researchers, collaborators, and external users through the BSIR.
• Training and consultation provided by facility staff for all levels of experience.
• To schedule time or learn more, visit https://bsir.fsu.edu.